Skip to main content
. Author manuscript; available in PMC: 2015 Feb 3.
Published in final edited form as: Angew Chem Int Ed Engl. 2014 Dec 12;54(6):1859–1863. doi: 10.1002/anie.201408817

Figure 4.

Figure 4

The C342T XPB mutant is resistant to triptolide in vitro and confers high-level triptolide resistance to HET293T cells. A) C342A, C342S, and C342T XPB mutant TFIIH complexes were resistant to triptolide at concentrations up to 100 μM and C342T-TFIIH has the highest ATPase activity. Mean values ± SD from two independent experiments are shown. B) A mutant knock-in cell line (T7115) expressing only the C342T XPB mutant is selectively resistant to triptolide in cell proliferation assay. Mean values ± SEM from four independent experiments are shown.