Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2016 Apr 1.

Published in final edited form as: Int J Cancer. 2014 Aug 22;136(7):1688–1696. doi: 10.1002/ijc.29132

Figure 2A. Temporal changes in the pO₂ of left and right hemisphere of (a) normal mice (n = 8) and (b) mice bearing U251 glioma in the right hemisphere (n=6) during 30% O₂, carbogen and 30% O₂ breathing. The experiment was repeated for five consecutive days. The bold lines are the mean response in the group obtained using an exponential quadratic function. The star symbol and horizontal line indicates the maximal pO₂ and time to reach maximal pO₂ on each day, respectively.

Figure 2B. Tissue pO₂ of the contralateral brain (●: CLB) and ipsilateral glioma ( : U251) in the (a) control (vehicle, n = 5); (b) gemcitabine (150 mg/kg, n = 5); (c) MK-8776 (50 mg/kg, n = 6), and (d) gemcitabine (150mg/kg) + MK-8776 (50 mg/kg) at 18 h (n = 8) measured using EPR oximetry with implantable resonator for five consecutive days. The mice were treated on day 1 after baseline pO₂ measurement. ^†p<0.05, ^‡p<0.01, compared with day 1; ^§p<0.01, compared with control group at the same day.

Figure 2A. Temporal changes in the pO₂ of left and right hemisphere of (a) normal mice (n = 8) and (b) mice bearing U251 glioma in the right hemisphere (n=6) during 30% O₂, carbogen and 30% O₂ breathing. The experiment was repeated for five consecutive days. The bold lines are the mean response in the group obtained using an exponential quadratic function. The star symbol and horizontal line indicates the maximal pO₂ and time to reach maximal pO₂ on each day, respectively.

Figure 2B. Tissue pO₂ of the contralateral brain (●: CLB) and ipsilateral glioma ( : U251) in the (a) control (vehicle, n = 5); (b) gemcitabine (150 mg/kg, n = 5); (c) MK-8776 (50 mg/kg, n = 6), and (d) gemcitabine (150mg/kg) + MK-8776 (50 mg/kg) at 18 h (n = 8) measured using EPR oximetry with implantable resonator for five consecutive days. The mice were treated on day 1 after baseline pO₂ measurement. ^†p<0.05, ^‡p<0.01, compared with day 1; ^§p<0.01, compared with control group at the same day.