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A) G-quartet structure stabilized by M+ (Na+, K+, etc.) B) CD spectroscopy was used to measure the melting temperature (Tm) of G-quadruplexes formed on the SNA and with linear G-rich DNA. The full CD spectra for C) G-rich DNA and D) G-rich SNAs are shown at increasing temperatures, demonstrating the enhanced thermal stability of G-quadruplexes formed on the SNA scaffold.
