Table 1.

Chemokines and chemokine receptors in TB

Receptor	Ligands	Role in TB	Reference
CCR2	CCL2,7,8,12,13,16	Recruitment of monocytes, DCs, T cells and NK cells.	[72–74]
CCR4	CCL17,22	Recruitment of T cells. May recruit NK cells, macrophages, DCs and basophils.	[75, 76]
CCR5	CCL3,4,5,8	Recruitment of T cells into the lung. May be involved in macrophage, DC and neutrophil migration.	[19, 75, 77]
CCR6	CCL20	iNKT and T cell recruitment.	[78, 79]
CCR7	CCL19,21	DC migration into the draining lymph nodes, recruitment of naïve and central memory cells to lymph nodes, ectopic lymphoid follicle formation.	[12–14, 26, 80]
CXCR1	CXCL6,8	Recruitment of neutrophils.	[81]
CXCR2	CXCL1,2,3,5,6,7,8	Recruitment of neutrophils and NK cells.	[73, 81, 82]
CXCR3	CXCL9,10,11	Recruitment of T cells into the lung.	[6, 18–20]
CXCR5	CXCL13	Ectopic lymphoid follicle formation.	[28]