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. Author manuscript; available in PMC: 2016 Feb 15.
Published in final edited form as: Dev Biol. 2014 Dec 16;398(2):255–266. doi: 10.1016/j.ydbio.2014.12.008

Fig. 7. NEKL-2 affects endocytosis of LRP-1::GFP from the apical surface of hyp7.

Fig. 7

The major localization of LRP-1::GFP in hyp7 of living worms changes from endosomes in the apical region (control RNAi in wild type) to a smeared pattern on the apical surface upon treatment with nekl-2 RNAi. The pattern resembles the apical accumulation of LRP-1::GFP conferred by dab-1(gk291). In contrast, subcellular localization of LRP-1::GFP is not strongly perturbed by nekl-3(sv3), qua-1(RNAi), or fbn-1(tm290), which also affect the completion of molting. For all LRP-1::GFP experiments, the strains contained the rrf-3(pk1426) mutation, which confers RNAi hypersensitivity. Scale bar = 5 µm. For additional information, see Fig. S3.