Figure 6.

Immunohistochemical analysis of NF-κB expression. (A, F and K) Normal control group, (B, G and L) NaTc + vehicle-treated group, (C, H and M) NaTc + AS-IV-treated group, (D, I and N) L-Arg + vehicle-treated group, and (E, J and O) L-Arg + AS-IV-treated group (original magnification, x400). Pre-treatment with AS-IV significantly decreased the staining intensity of NF-κB in the nucleus, particularly at the time point of 12 h after the induction of AP. Results are representative of 3 independent experiments. AS-IV, astragaloside IV; NaTc, sodium taurocholate; L-Arg, L-arginine; AP, acute pancreatitis; NF-κB, nuclear factor-κB.