Skip to main content
. 2015 Jan 20;35(3):607–616. doi: 10.3892/ijmm.2015.2073

Figure 2.

Figure 2

Adpa-Mn exhibits selective inhibition on cancer cell proliferation through the transferrin/transferrin receptor (Tf-1/TfR-1) system. HepG2 cells and WRL-68 cells were treated with various concentrations of (A) Adpa-Mn or (B) cisplatin for 24 h and cell viability was detected by MTT assay. HepG2 cells were pre-treated with deferoxamine (DFO; 10 μM) (C) or ferric citrate (100 μM) (D) for 24 h, then treated with various concentrations of Adpa-Mn for 24 h. (E) The expression of TfR-1 in HepG2 and WRL-68 cells. Data represent the means ± SEM of 3 different experiments. *p<0.05 and **p<0.01 vs. the respective control.