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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Genomics. 2014 Nov 28;105(2):108–115. doi: 10.1016/j.ygeno.2014.11.007

Fig. 4. AEBP2 involvement in the transcriptional activity of Jarid2, Snai2 and Aebp2.

Fig. 4

The expression vectors producing the somatic (Aebp2-S) and embryonic (Aebp2-e) form of AEBP2 were co-transfected to HEK293T cells along with the β-Gal reporter constructs containing the promoters of Jarid2 (A), Aebp2 (B) and Snai2 (C). The somatic form (Aebp2-S) increased the transcriptional activity of all three promoters, indicating that the somatic form functions as an activator. In contrast, the embryonic form (Aebp2-e) decreased the transcriptional activity of the promoters of Snai2, but not Aebp2 and Jarid2. This indicates that the embryonic form may be a locus-specific repressor.