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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Genomics. 2014 Nov 28;105(2):108–115. doi: 10.1016/j.ygeno.2014.11.007

Fig. 6. A model for the repressor and activator roles of AEBP2.

Fig. 6

A) A repressor role through the PRC2 in uncommitted stem cells. The embryonic from of AEBP2 and JARID2 are responsible for recruiting the PCR2 to PcG genes for their temporary repression in uncommitted stem cells. B) An activator role through a hypothetical activation complex in committed stem cells. The somatic form activates the transcription of itself and Jarid2 to form an activator complex, which competes and eventually replaces the PRC2 to turn on some of the temporary repressed PcG genes in committed stem cell lineages.