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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Cell Signal. 2014 Oct 29;27(1):147–155. doi: 10.1016/j.cellsig.2014.10.009

Figure 10.

Figure 10

Model of ERK1 activation with respect to G protein signaling pathways. Signals mediated by G protein signaling pathways in response to cAMP and folate activate ERK2 but then later lead to the activation of ERK1 in a secondary response. ERK1 can also be activated through intercellular signaling. The Gα5-mediated signaling pathway can down regulate ERK1 function but not through changing the phosphorylated state of ERK1.