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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Am Soc Hypertens. 2014 Oct 23;9(1):15–20. doi: 10.1016/j.jash.2014.10.009

Figure 3. The mean effect of sera from primary aldosteronism patients and normotensive control subjects in the absence and presence of AT1R blockade on AT1R activation in transfected CHO cells.

Figure 3

Both IAH and APA had a highly significant increase of AT1R activity compared to the normotensive controls (*P<0.01, **P<0.001). There was no significant difference in AT1R activity between the two primary aldosteronism groups. The AT1R blocker losartan (10 μM) effectively blocked the autoantibody activity in each group of the primary aldosteronism patients (#P<0.01). Although the activity in IAH and APA dropped significantly with losartan, there was no significant change in the low level of activity in the control subjects.