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. 2015 Jan 23;5(1):e274. doi: 10.1038/bcj.2014.96

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Inhibition of either autophagy or ubiquitination fails to degrade E2A/Pbx1. Flow cytometry (a) showed that inhibition of autophagy by 3-MA and inhibition of ubiquitination by ubiquitin-proteasome inhibitor MG132 fails to degrade E2A/Pbx1, and the oncoprotein accumulated in the combined group in western botting result (b), indicating that both autophagy and ubiquitination contribute to the degradation of E2A/Pbx1. Nutrient depletion with HBSS medium also induced ubiquitination of 697 cells (c), and MG132 restored the degradation of E2A/Pbx1 induced by nutrient depletion with HBSS (d).