Table 1.
Mean (± SD) values of demographic, clinical, cognitive, geriatric depression scale, levodopa equivalent dose (LED), cortical AChE hydrolysis rate (k3; min−1) and striatal [11C]DTBZ VMAT2 distribution volume ratio (DVR) in the patients with PD with and without comorbid DM. Gender distribution is presented as proportions. Levels of statistical difference between groups are also presented.
| PD subjects with diabetes (n =15) |
PD subjects without diabetes (n=133) |
Group comparison (significance) |
|
|---|---|---|---|
| Age (yr) | 67.3±6.1 | 65.4±7.5 | t=0.95, P=0.35 |
| Gender (M/F) | 13/2 | 96/37 | χ2=1.46, P=0.23 |
| Caucasian | 15 (100%) | 125 (94%) | χ2=0.95, P=0.33 |
| Duration of motor PD (yr) | 5.8±4.4 | 6.1±4.3 | t=0.20, P=0.84 |
| Education (yr) | 14.1±3.1 | 15.5±2.8 | t=1.85, P=0.07 |
| LED (mg) | 890±756 | 673±508 | t=1.48, P=0.17 |
| Selegiline use | 1 (6.7%) | 7 (5.3%) | χ2=0.05, P=0.82 |
| Hoehn & Yahr stage | 2.7±0.7 | 2.4±0.5 | t=1.61, P=0.11 |
| Geriatric depression scale | 8.8±7.9 | 5.9±5.1 | tapprox=1.27, P=0.22 |
| Striatal VMAT2 DVR | 1.97±0.38 | 1.92±0.28 | t=0.60, P=0.55 |
| Cortical AChE hydrolysis rates | 0.0247±0.0036 | 0.0235±0.0027 | t=1.55, P=0.12 |
tapprox= Satterthwaite’s method of approximate t tests.