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. 2014 Dec 4;4(2):93–105. doi: 10.1016/j.molmet.2014.11.006

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© 2014 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

PMC Copyright notice

sR3 mice have an increased ratio of M2/M1 polarized macrophages in subcutaneous adipose tissue. (A) Representative FACS plots. (B) FACS analyses showed that sR3 mice had an increase in CD11b⁺/F4/80⁺ macrophages, as well as higher ratios of M2/M1 polarized macrophages. This difference was due to decreased expression of MHCII and increased expression of CD206 in the CD11b⁺/F4/80⁺ macrophages within the stromal-vascular fraction (n = 3–7, two-tailed Student's t-test, *P < 0.05, **P < 0.01). All data are mean ± SD.