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. 2014 Nov 13;4(2):144–150. doi: 10.1016/j.molmet.2014.11.003

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© 2014 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Central infusion of recombinant Angptl4 or vehicle does not change food intake or body weight in mice fed either a chow diet (CD) or high fat diet (HFD). A) Food intake in C57Bl/J6 mice infused with vehicle (closed symbols) or recombinant Angptl4 (10 ng/h) (open symbols) on either CD (circles) or HFD (squares) (n = 5 per group). B) Show the delta change in bodyweight in the C57Bl/J6 mice infused with vehicle or recombinant Angptl4 (10 ng/h) on either CD or HFD (n = 5 per group). C) mRNA expression of NPY, POMC, CART and AgRP in hypothalamus of Angptl4 knockout (Angptl4^−/−) mice and their wildtype (Angptl4^+/+) controls. (n = 6–8 per group). Data are mean ± SEM. * = p ≤ 0.05 Student's t-test compared to vehicle.