Table 1.
Host- and Treatment-Related Characteristics of Cancer Survivors and Siblings
| Characteristic | Survivor Group (n = 22,568; %)* | Sibling Group (n = 7,504; %)* | χ2 P |
|---|---|---|---|
| Sex | < .0001 | ||
| Male | 51.9 | 46.4 | |
| Female | 48.1 | 53.6 | |
| Race/ethnicity | < .0001 | ||
| White | 88.8 | 89.2 | |
| Black | 3.7 | 2.2 | |
| Hispanic | 4.6 | 2.9 | |
| Other | 2.6 | 2.4 | |
| Not reported | 0.4 | 3.3 | |
| High school graduate | < .0001 | ||
| Yes | 87.4 | 91.5 | |
| No | 6.3 | 3.5 | |
| Not reported | 6.3 | 5.1 | |
| Annual household income | < .0001 | ||
| < $20,000 | 14.2 | 7.3 | |
| ≥ $20,000 | 74.7 | 85.6 | |
| Not reported | 11.0 | 7.0 | |
| Health insurance | < .0001 | ||
| Yes/Canadian | 86.8 | 90.0 | |
| No | 12.0 | 9.2 | |
| Not reported | 1.2 | 0.7 | |
| Body mass index, kg/m2† | < .0001 | ||
| Underweight | 4.7 | 2.5 | |
| Normal | 48.0 | 46.2 | |
| Overweight | 29.1 | 30.7 | |
| Obese | 18.2 | 20.6 | |
| Heavy/binge drinker‡ | < .0001 | ||
| Yes | 10.4 | 13.3 | |
| No | 89.6 | 86.7 | |
| Smoking status | < .0001 | ||
| Never | 71.5 | 61.3 | |
| Former | 11.2 | 16.4 | |
| Current | 17.2 | 22.3 | |
| Meets CDC physical activity guidelines§ | < .0001 | ||
| Yes | 70.6 | 77.2 | |
| No | 29.4 | 22.8 | |
| Grade 3-4 chronic conditions | < .0001 | ||
| One | 25.7 | 9.8 | |
| Two or more | 10.9 | 1.7 | |
| Age group picked on questionnaire, years | < .0001 | ||
| 18-24 | 18.2 | 13.4 | |
| 25-29 | 18.7 | 17.3 | |
| 30-34 | 24.1 | 21.8 | |
| 35-39 | 19.4 | 19.9 | |
| 40-44 | 12.1 | 15.1 | |
| ≥ 45 | 7.4 | 12.6 | |
| Age at diagnosis, years | |||
| Mean | 9.5 | ||
| Standard deviation | 5.6 | ||
| Range | 0-20 | ||
| Time from cancer diagnosis, years | |||
| Mean | 22.4 | ||
| Standard deviation | 6.8 | ||
| Range | 6-39 | ||
| Diagnosis | |||
| Leukemia | 30.4 | ||
| CNS malignancy | 12.4 | ||
| Hodgkin's lymphoma | 17.1 | ||
| Non-Hodgkin's lymphoma | 9.1 | ||
| Wilms tumor | 6.7 | ||
| Neuroblastoma | 4.1 | ||
| Soft-tissue sarcoma | 9.6 | ||
| Bone malignancy | 10.6 | ||
| Select chemotherapy exposures | |||
| Anthracycline agents | 26.9 | ||
| Alkylating agents | 52.0 | ||
| Brain radiation, maximum dose, Gy | |||
| None | 66.9 | ||
| 3.0-23.9 | 9.2 | ||
| 24.0-29.9 | 12.8 | ||
| ≥ 30.0 | 11.1 | ||
| Chest radiation, maximum dose, Gy | |||
| None | 71.6 | ||
| 6.2-23.9 | 7.4 | ||
| 24.0-37.9 | 11.4 | ||
| ≥ 38.0 | 9.6 | ||
| Abdominal radiation, maximum dose, Gy | |||
| None | 74.2 | ||
| 14.0-23.9 | 7.0 | ||
| 24.0-34.9 | 8.6 | ||
| ≥ 35.0 | 10.2 | ||
| Pelvic radiation, maximum dose, Gy | |||
| None | 79.7 | ||
| 6.1-23.9 | 5.3 | ||
| 24-34.9 | 6.7 | ||
| ≥ 35.0 | 8.3 | ||
| Surgery | |||
| Craniotomy | 10.1 | ||
| Thoracotomy | 4.4 | ||
| Nephrectomy | 5.8 | ||
| Cystectomy | 0.7 | ||
| Upper extremity amputation | 0.5 | ||
| Lower extremity amputation | 4.8 | ||
Abbreviations: BMI, body mass index; CDC, Centers for Disease Control and Prevention.
Represents 9,711 survivors and 3,206 siblings who completed the baseline questionnaire; 6,875 survivors and 2,351 siblings who completed the 2003 questionnaire; and 5,982 survivors and 1,947 siblings who completed the 2007 questionnaire.
BMI was categorized as underweight (< 18.5 kg/m2), normal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2) or obese (≥ 30 kg/m2).
Heavy/binge drinking was assigned to male participants who reported consuming > 4 drinks/day or > 14 drinks/week and to female participants who reported consuming > 3 drinks/day or > 7 drinks/week.
The equivalent of at least 150 minutes moderate physical activity per week.