. 2014 Dec 29;33(5):479–491. doi: 10.1200/JCO.2014.57.4863

Table 3.

Prevalence Ratios and 95% CIs for Adverse Health Status Outcomes by Host and Treatment-Related Factors Among Survivors

Variable	Poor General Health		Adverse Mental Health		Functional Impairment		Activity Limitations		Cancer-Related Pain		Cancer-Related Anxiety		Adverse Outcome in Any Domain
Variable	PR	95% CI	PR	95% CI	PR	95% CI	PR	95% CI	PR	95% CI	PR	95% CI	PR	95% CI
Sex
Male	Reference		Reference		Reference		Reference		Reference		Reference		Reference
Female	1.20	1.06 to 1.35	1.16	1.05 to 1.29	1.45	1.30 to 1.61	1.96	1.74 to 2.21	1.23	1.07 to 1.41	1.73	1.55 to 1.94	1.51	1.40 to 1.64
Race/ethnicity
White	Reference		Reference		Reference								Reference
Nonwhite	1.41	1.18 to 1.68	1.10	0.93 to 1.29	1.32	1.12 to 1.55							1.12	0.99 to 1.27
Age at interview, years
18-24	Reference				Reference		Reference		Reference				Reference
25-29	1.74	1.44 to 2.10			1.62	1.37 to 1.91	1.20	1.00 to 1.43	1.19	0.99 to 1.44			1.13	1.02 to 1.26
30-34	1.95	1.63 to 2.33			2.15	1.84 to 2.51	1.32	1.11 to 1.57	1.18	0.97 to 1.42			1.20	1.09 to 1.33
35-39	2.29	1.89 to 2.77			2.82	2.38 to 3.33	1.89	1.56 to 2.29	1.11	0.90 to 1.37			1.27	1.14 to 1.42
40-44	2.81	2.29 to 3.45			3.50	2.89 to 4.23	2.42	1.96 to 2.98	1.14	0.90 to 1.45			1.28	1.13 to 1.46
≥ 45	3.52	2.79 to 4.43			4.54	3.63 to 5.66	3.57	2.82 to 4.51	0.93	0.69 to 1.27			1.63	1.40 to 1.90
Age at diagnosis, years
0-4							Reference		Reference
5-9							1.18	0.96 to 1.45	0.78	0.62 to 0.98
10-14							0.99	0.82 to 1.19	0.75	0.61 to 0.92
15-20							0.93	0.79 to 1.09	0.89	0.74 to 1.06
Income < $20,000/year
Yes	2.25	1.98 to 2.56	1.84	1.65 to 2.05	2.46	2.18 to 2.77	2.14	1.87 to 2.44	2.02	1.75 to 2.35	1.51	1.33 to 1.72	1.89	1.72 to 2.08
No	Reference		Reference		Reference		Reference		Reference		Reference		Reference
High school graduate
Yes	Reference		Reference		Reference		Reference		Reference		Reference		Reference
No	2.14	1.76 to 2.60	1.43	1.19 to 1.73	2.65	2.22 to 3.16	1.85	1.51 to 2.27	1.48	1.16 to 1.89	1.23	0.99 to 1.51	1.90	1.63 to 2.22
Body mass index
< 18.5 kg/m²	1.70	1.35 to 2.13	1.12	0.92 to 1.38	1.45	1.17 to 1.80	1.65	1.32 to 2.07	1.43	1.11 to 1.84			1.44	1.22 to 1.69
18.5-24.9 kg/m²	Reference		Reference		Reference		Reference		Reference				Reference
25.0-29.9 kg/m²	1.15	1.01 to 1.30	1.08	0.97 to 1.20	1.09	0.98 to 1.23	1.10	0.97 to 1.25	1.10	0.95 to 1.28			1.08	0.99 to 1.17
≥ 30 kg/m²	1.83	1.59 to 2.11	1.24	1.10 to 1.41	1.27	1.11 to 1.45	1.61	1.40 to 1.85	1.25	1.05 to 1.50			1.32	1.20 to 1.46
Smoking status
Never	Reference		Reference		Reference		Reference		Reference		Reference		Reference
Former	1.50	1.27 to 1.77	1.53	1.33 to 1.75	1.46	1.26 to 1.69	1.05	0.89 to 1.24	1.62	1.35 to 1.94	1.24	1.06 to 1.45	1.35	1.21 to 1.51
Current	1.91	1.66 to 2.20	1.92	1.71 to 2.16	1.12	0.98 to 1.28	1.07	0.92 to 1.24	1.58	1.35 to 1.86	1.25	1.09 to 1.44	1.44	1.31 to 1.60
Meets CDC physical activity guidelines^*
Yes	Reference		Reference		Reference		Reference		Reference		Reference		Reference
No	1.89	1.70 to 2.10	1.26	1.15 to 1.38	1.62	1.47 to 1.79	1.89	1.71 to 2.10	1.22	1.07 to 1.39	1.10	0.99 to 1.22	1.31	1.22 to 1.41
Anthracyclines
Yes	1.15	1.00 to 1.33					1.31	1.13 to 1.51	1.32	1.12 to 1.54	1.14	1.00 to 1.29	1.11	1.01 to 1.22
No	Reference						Reference		Reference		Reference		Reference
Alkylating agents
Yes	1.26	1.10 to 1.44	1.19	1.08 to 1.32	1.21	1.08 to 1.35	1.18	1.03 to 1.35	1.18	1.02 to 1.37	1.20	1.06 to 1.36	1.16	1.06 to 1.27
No	Reference		Reference		Reference		Reference		Reference		Reference		Reference
Cranial radiation, Gy
None	Reference				Reference		Reference		Reference				Reference
3.0-23.9	0.83	0.66 to 1.04			1.01	0.83 to 1.24	0.80	0.64 to 1.01	0.78	0.59 to 1.03			0.98	0.85 to 1.13
24.0-29.9	1.02	0.84 to 1.24			1.00	0.83 to 1.19	0.72	0.58 to 0.89	1.05	0.84 to 1.32			1.05	0.92 to 1.19
≥ 30.0	1.52	1.21 to 1.91			2.39	1.97 to 2.92	1.28	1.02 to 1.60	1.14	0.91 to 1.43			1.63	1.39 to 1.91
Chest radiation, Gy
None	Reference				Reference		Reference						Reference
6.2-23.9	1.33	1.06 to 1.65			0.98	0.81 to 1.20	1.20	0.92 to 1.56					1.22	1.05 to 1.41
24.0-37.9	1.35	1.12 to 1.62			0.90	0.76 to 1.07	1.36	1.09 to 1.69					1.20	1.05 to 1.37
≥ 38.0	1.27	1.04 to 1.55			1.18	0.99 to 1.41	1.55	1.22 to 1.95					1.28	1.12 to 1.47
Abdominal radiation, Gy
None							Reference				Reference
1.4-23.9							1.02	0.77 to 1.36			0.96	0.75 to 1.22
24.0-34.9							0.77	0.60 to 0.99			1.11	0.90 to 1.37
≥ 35.0							1.03	0.82 to 1.29			1.34	1.12 to 1.60
Craniotomy
Yes	1.19	0.94 to 1.52	1.23	1.05 to 1.44	1.82	1.48 to 2.23	1.47	1.17 to 1.86					1.27	1.08 to 1.49
No	Reference		Reference		Reference		Reference						Reference
Thoracotomy
Yes											1.32	1.05 to 1.67	1.24	1.04 to 1.47
No											Reference		Reference
Nephrectomy
Yes					0.84	0.66 to 1.07					0.79	0.61 to 1.03
No					Reference						Reference
Cystectomy
Yes	2.69	1.56 to 4.63			2.46	1.46 to 4.16	3.49	2.04 to 5.98	2.22	1.28 to 3.83			1.61	1.05 to 2.49
No	Reference				Reference		Reference		Reference				Reference
Lower extremity amputation
Yes					1.94	1.58 to 2.38	2.82	2.29 to 3.49	2.50	1.98 to 3.15			2.14	1.79 to 2.56
No					Reference		Reference		Reference				Reference
Upper extremity amputation
Yes					1.72	0.85 to 3.47			2.85	1.54 to 5.30
No					Reference				Reference

Abbreviations: CDC, Centers for Disease Control and Prevention; PR, prevalence ratio.

At least 150 minutes per week of moderate physical activity. For each outcome, all generalized estimating equations were adjusted for other host- and treatment-related risk factors with a reported PR and for within-person correlation. Variables with P < .10 were retained using backward selection criteria.