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. 2015 Feb 3;5:8209. doi: 10.1038/srep08209

Figure 1. Effects of ACE2 and Mas–receptor antagonist A779 on apoptosis of PMVECs treated with LPS for 48 h.

Figure 1

(A) LPS exposure caused a significant apoptosis in PMVECs but was attenuated by ACE2 overexpression and aggravated by ACE2 downregulation. (B) LPS–induced apoptosis was markedly increased by A779 pretreatment but was improved by ACE2 overexpression. There was no significant difference between the ACE2 + A779 + LPS group and LPS group in apoptosis. All data are expressed as mean ± SD. * P < 0.05 compared with PBS control group; #P < 0.05 compared with LPS group.