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Hypothetical 3-dimensional structure of amyloid precursor protein (APP) based on the following protein data bank files: E1 domain (3KTM), Kunitz protease inhibitor (KPI) domain (1ZJD), E2 domain (3UMK), transmembrane domain (TMD) (2LLM) and intracellular domain (3DXC). A cholesterol molecule is shown in the proposed lipid-binding site in the transmembrane domain. The acidic region and the region between the E2 and Aβ domains are predicated to have little secondary structure.
