Table 1.

Genes harboring differentially methylated loci between hip osteoarthritis (OA) and femoral neck fracture samples

Gene	Mean β value		P, after Benjamini-Hochberg correction
	Femoral neck fracture patients	Hip OA patients
Hypermethylated in OA
ACVR1B	0.42	0.53	0.00091
ADAMTS2	0.47	0.58	0.0081
ADAMTS8	0.49	0.60	0.00045
BMPR1A	0.60	0.70	0.038
BMPR1B	0.35	0.60	0.000031
COL2A1	0.24	0.37	0.010
COL5A3	0.29	0.42	0.000030
COL9A1	0.57	0.69	0.0035
COL9A3	0.27	0.38	0.0091
COL11A2	0.27	0.47	0.000013
COL13A1	0.21	0.31	0.018
IL17B	0.32	0.42	0.0060
MCF2L	0.46	0.56	0.0043
MMP16	0.63	0.75	0.00020
PTHLH	0.15	0.28	0.000030
SMAD2	0.32	0.46	0.0033
SMAD3	0.69	0.81	0.000048
SUPT3H	0.55	0.68	0.0071
TGFB2	0.32	0.47	0.032
TGFBR2	0.61	0.72	0.00011
Hypomethylated in OA
ACVR1	0.87	0.76	0.00096
ADAMTS4	0.65	0.52	0.00040
ADAMTS5	0.75	0.60	0.0000031
ADAMTS10	0.82	0.65	0.00079
ADAMTS17	0.59	0.43	0.00015
BMP1	0.33	0.22	0.00000030
BMP6	0.34	0.22	0.00060
CHST11	0.83	0.70	0.0031
COL1A2	0.58	0.42	0.0022
COL6A3	0.57	0.44	0.00093
COL7A1	0.36	0.24	0.000025
COL8A1	0.80	0.66	0.00055
COL22A1	0.49	0.38	0.0040
ECM1	0.59	0.47	0.00061
FILIP1	0.54	0.37	0.00022
IL4R	0.53	0.34	0.0015
MMP13	0.73	0.60	0.0025
PBRM1	0.83	0.68	0.000017
TGFB1	0.42	0.27	0.031
TGFBR3	0.39	0.28	0.016