Table 2.

Genes harboring differentially methylated loci between the 2 hip osteoarthritis clusters

Gene	Mean β value		P, after Benjamini-Hochberg correction
	Cluster 1	Cluster 2
Hypermethylated in cluster 2
ACAN	0.68	0.79	0.0035
ADAMTS2	0.23	0.37	0.00093
ADAMTS7	0.41	0.55	0.0020
ADAMTS9	0.23	0.37	0.031
ADAMTS10	0.55	0.66	0.0012
ADAMTS14	0.44	0.59	0.033
BMP2	0.28	0.56	0.00058
BMP4	0.42	0.54	0.0096
BMP6	0.27	0.39	0.029
BMP8A	0.69	0.84	0.0069
BMPR1A	0.32	0.48	0.025
COL2A1	0.21	0.34	0.0011
GDF5	0.66	0.79	0.000078
IL6	0.43	0.58	0.027
IL10	0.15	0.35	0.017
IL16	0.71	0.82	0.035
IL17B	0.41	0.58	0.0017
MCF2L	0.26	0.48	0.0033
MMP2	0.39	0.52	0.00028
MMP20	0.14	0.29	0.025
MMP28	0.25	0.41	0.028
SMAD5	0.62	0.73	0.018
SMAD7	0.44	0.59	0.00019
Hypomethylated in cluster 2
ACVR1	0.83	0.71	0.033
ADAM11	0.41	0.31	0.022
ADAM12	0.89	0.75	0.021
ADAM19	0.82	0.66	0.046
ADAMTS1	0.52	0.32	0.017
ADAMTS5	0.31	0.18	0.0026
ADAMTS6	0.64	0.51	0.026
ADAMTSL2	0.58	0.40	0.016
CHST11	0.43	0.21	0.0052
ECM1	0.55	0.39	0.00042
IL2	0.51	0.34	0.031
IL3	0.52	0.35	0.0028
IL15	0.55	0.40	0.015
IL17C	0.45	0.34	0.032
IL4R	0.47	0.23	0.00035
MMP19	0.39	0.24	0.0045
SMAD3	0.60	0.43	0.020
TGFB1	0.34	0.22	0.032
SMAD3	0.25	0.15	0.048