Table 3.

Genes harboring differentially methylated loci between the 2 knee osteoarthritis clusters

Gene	Mean β value		P, after Benjamini-Hochberg correction
	Cluster 1	Cluster 2
Hypermethylated in cluster 2
ACVR2B	0.52	0.62	0.0000021
ADAMTSL1	0.47	0.59	0.0039
ADAMTSL3	0.61	0.71	0.0000027
BMP2	0.32	0.45	0.000026
BMP5	0.38	0.51	0.0000055
COL2A1	0.31	0.44	0.00000000016
COL6A3	0.18	0.29	0.00000033
FGF1	0.24	0.36	0.0000013
IL10	0.14	0.25	0.000021
IL16	0.44	0.58	0.000000016
IL18	0.29	0.41	0.00020
IL19	0.39	0.49	0.000046
MMP28	0.45	0.56	0.000000064
MTOR	0.24	0.38	0.0000034
SMAD2	0.46	0.58	0.00000011
SMAD7	0.19	0.29	0.000020
TGFB1	0.48	0.62	0.00000096
TGFB2	0.39	0.51	0.00088
Hypomethylated in cluster 2
ACVR1	0.78	0.67	0.0000000081
ADAM12	0.84	0.74	0.000000011
ADAM32	0.77	0.65	0.000016
ADAMTS10	0.70	0.51	0.00000000066
ADAMTS12	0.54	0.44	0.00057
CHST11	0.75	0.64	0.00000021
IL2	0.50	0.39	0.00070
IL4R	0.42	0.27	0.000000000078
IL6R	0.63	0.49	0.000084
MMP19	0.37	0.26	0.000000010
RUNX1	0.65	0.46	0.000000037
RUNX2	0.69	0.55	0.000011
RUNX3	0.71	0.59	0.0000034
SMAD3	0.63	0.48	0.0000000020
TGFBR2	0.67	0.48	0.0000000025
TGFBR3	0.56	0.41	0.0000000023
TIMP2	0.87	0.76	0.000011