Table 4.

Genes harboring differentially methylated loci between hip and knee osteoarthritis (OA) samples

Gene	Mean β value		P, after Benjamini-Hochberg correction
	Knee OA patients	Hip OA patients
Hypermethylated in hip OA
ADAM12	0.70	0.83	0.00000000015
ADAM7	0.17	0.28	0.000033
ADAMTS2	0.77	0.88	0.00000016
ADAMTS5	0.51	0.66	0.000080
ADAMTS17	0.27	0.42	0.0000049
COL6A3	0.43	0.63	0.00000000083
IL17RD	0.48	0.65	0.000000034
IL18	0.35	0.46	0.0047
IL1RN	0.47	0.59	0.0000016
RUNX3	0.59	0.74	0.000000000025
TGFB2	0.21	0.32	0.00073
Hypomethylated in hip OA
ADAMTS9	0.42	0.31	0.00036
BMP6	0.31	0.19	0.0011
BMP7	0.46	0.33	0.0000022
CHST11	0.65	0.53	0.0000026
COL4A2	0.60	0.44	0.00000020
COL18A1	0.68	0.58	0.00000000018
FGF1	0.66	0.56	0.0084
FGFR3	0.66	0.55	0.00014
GDF5	0.85	0.73	0.000049
IL10	0.69	0.56	0.000018
MCF2L	0.51	0.40	0.0013
PCOLCE	0.46	0.33	0.00015
SMAD7	0.78	0.62	0.0000018
TGFBR2	0.59	0.49	0.0065