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. Author manuscript; available in PMC: 2015 Feb 3.
Published in final edited form as: Oncogene. 2013 Oct 14;33(38):4643–4652. doi: 10.1038/onc.2013.412

Figure 6.

Figure 6

Analysis of the role of matriptase and HAI-2 in prostate tumor growth and metastasis in xenografted mice. Matriptase (MTX) knockdown (shMTX)/scramble RNA N2 cells and HAI-2-overexpressing/vector-transfected N2 cells were orthotopically xenografted into the anterior prostate of mice (six mice per group). (A) Tumor growth was statistically analyzed employing bioluminescence intensity after the measurement using the IVIS system (Xenogen) once a week after i.p. injection of D-luciferin at 150 mg/kg. (B) Six weeks after implantation, the tumors were excised, images and weighed. The average tumor masses from scramble RNA/shMTX N2, vector-transfected and HAI-2-overexpressing N2 xenografted mice were 6.201±0.7007, 3.643±0.2822, 5.879±0.801, and 2.781±0.3880 grams (n=6, mean±SE), respectively. Three images per group are presented to represent tumor sizes. The tumor masses in 6 xenografted mice were calculated and presented as mean±SD. *, P< 0.05; **, P<0.01. (C) Analysis of the metastatic lesions in xenografted mice. The metastatic lesions in lung tissues of mice were imaged by the IVIS system (Xenogen) after i.p. injection of D-luciferin at 150 mg/kg (upper panels) and their bioluminescence intensities were statistically plotted and calculated (lower panels).