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. 2015 Jan 27;13:26. doi: 10.1186/s12967-015-0385-4

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© Porcelli et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Determinants of resistance to vemurafenib. A. Cell cycle progression of the two pair of cells, MBA72/ MBA72R and Hmel-1/Hmel-1R, were determined as described in M&M section. B. p-Erk1/2, Erk1/2, p-Akt, Akt, p-p38 MAPK and p38 MAPK were analysed in cells by western blotting and protein amount determined by densitometry analysis. Histograms are means of at least three different experiments. *p < 0.05 vs untreated cells. C. The expression level of MITF was determined by FCM in MBA72, MBA72R and HBL as respect to the isotype.