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Effect of barasertib-HQPA and vemurafenib on lactate production. In A, extracellular lactate level was measured in the growth medium of cells exposed to either vehicle or barasertib (Bar) or vemurafenib (Vem) after 3 days. Data are means ± SEM and significance was calculated with Student’s t test; *p < 0.05 vs untreated cells. In B, the curve of the release of lactate are shown in function of barasertib-HQPA concentration (3, 30, 300 nM) and after 6 days of drug exposure.
