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Vemurafenib and barasertib activity evaluation in living cell lines
| Cell line | BRAF status | 3 days-vemurafenib | 3 days-barasertib-HQPA |
|---|---|---|---|
| IC 50 (μM) | IC 50 (nM) | ||
| MBA72 | V600E | 3.2 ± 0.6 | 305 ± 4 |
| Hmel-1 | V600K | 5.5 ± 0.4 | 311 ± 6 |
| LND1 | wild type | 32.2 ± 1.1 | 307 ± 7 |
| HBL | wild type | 37.3 ± 0.9 | 315 ± 11 |
| MBA72R | V600E | 33.5 ± 0.5 | 367 ± 10 |
| Hmel-1R | V600K | 25.8 ± 0.5 | 184 ± 8 |
