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. 2015 Jan 29;8:6. doi: 10.1186/s13041-015-0096-z

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© Tiwari et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CSPalpha expression is increased in Alzheimer’s disease cerebellum. (A) CSPalpha expression in post-mortem cerebellum from patients with severe Alzheimer’s disease (n = 10; average age at death = 74.7 ± 4.0 years) and control subjects (n = 10; average age at death = 76.3 ± 4.2 years). CSPalpha expression was normalized against NSE. (B) CSPalpha expression in post-mortem cerebellum from patients with mild Alzheimer’s disease (n = 10; average age at death = 81.3 ± 4.1 years) and control subjects (n = 10). CSPalpha expression was normalized against NSE. (C) The same samples as in panel (A) were used but CSPalpha expression was normalized against synaptophysin. (D) The same samples as in panel (B) were used but CSPalpha expression was normalized against synaptophysin. Panel (E) shows the representative western blots for 5 controls, 5 patients with mild AD and 5 patients with severe AD. Means ± s.e.m. are shown. *, p < 0.05; **, p < 0.01.