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. 2015 Jan 29;8:6. doi: 10.1186/s13041-015-0096-z

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© Tiwari et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Mice expressing human tau have an age-dependent CSPalpha upregulation that correlates with neuroprotection. (A) CSPalpha expression in hippocampus of young (3–4 months) wild type (n = 6) and htau mice (n = 6). (B) CSPalpha expression in cortex of young (3–4 months) wild type (n = 6) and htau mice (n = 6). (C) CSPalpha expression in cerebellum of the same mouse sample as in panel (A) and (B). (D) CSP alpha expression in old (24 months) wild type (n = 4) and htau mice (n = 7). CSPalpha expression was normalized against NSE in all panels. Panel (E) shows the representative western blots. Means ± s.e.m are shown. ***, p < 0.001.