Table 2.
Adjusted Odds Ratios and 95% Confidence Intervals for CHD risk by different genotypes of the uric acid related SNPs in CHD cases and controls
| SNPs gene location | Genotypes | Cases n (%) | Controls n (%) | Age- and sex- adjusted | P value | Multivariate model 1 a | P value | Multivariate model 2 b | P value | Multivariate model 3 c | P value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs11722228 | CC | 564(50.2) | 586(52.7) | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| SLC2A9 | CT | 472(42.0) | 449(40.3) | 1.09(0.92-1.30) | 0.319 | 1.14(0.95-1.37) | 0.175 | 1.08(0.89-1.31) | 0.445 | 1.06(0.85-1.32) | 0.611 |
| 4p16.1 | TT | 87(7.8) | 78(7.0) | 1.16(0.83-1.60) | 0.388 | 1.19(0.84-1.69) | 0.322 | 1.05(0.73-1.51) | 0.801 | 1.27(0.84-1.93) | 0.262 |
| CT+TT | 559(49.8) | 527(47.3) | 1.10(0.93-1.30) | 0.268 | 1.15(0.96-1.37) | 0.135 | 1.07(0.89-1.29) | 0.452 | 1.09(0.88-1.35) | 0.433 | |
| rs4148152 | AA | 533(47.4) | 463(42.0) | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| ABCG2 | AG | 479(42.6) | 530(48.1) | 0.78(0.66-0.93) | 0.006 | 0.80(0.66-0.97) | 0.019 | 0.85(0.70-1.03) | 0.088 | 0.92(0.74-1.16) | 0.483 |
| 4q22 | GG | 112(10.0) | 109(9.9) | 0.89(0.67-1.20) | 0.445 | 0.81(0.59-1.11) | 0.192 | 0.81(0.58-1.12) | 0.200 | 0.77(0.53-1.13) | 0.182 |
| AG+GG | 591(52.6) | 639(58.0) | 0.80(0.68-0.95) | 0.010 | 0.80(0.67-0.96) | 0.015 | 0.84(0.70-1.01) | 0.062 | 0.89(0.72-1.11) | 0.306 |
a, adjusted for age (continuous), sex (male, female), smoking (yes/no), drinking (yes/no) and family history of CHD (yes/no).
b, adjusted for the same set of variables in model 1 plus BMI (continuous).
c, adjusted for the same set of variables in model 2 plus total cholesterol (continuous), triglyceride (continuous), and the history of hypertension and diabetes (yes/no).