Table 3.
Stratified associations of SNPs rs11722228 and rs4148152 with CHD risk by CHD traditional risk factors
| rs11722228 ORs (95% CIs) | P | rs4148152 ORs (95% CIs) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variables | CC | CT | TT | CT+TT | P | AA | AG | GG | AG+GG | P |
| Sex | ||||||||||
| Male | 1.00 | 1.07(0.86-1.33) | 1.14(0.75-1.71) | 1.08(0.87-1.33) | 0.62 | 1.00 | 0.83(0.67-1.03) | 0.83(0.58-1.21) | 0.83(0.67-1.02) | 0.86 |
| Female | 1.00 | 1.19(0.78-1.81) | 0.77(0.34-1.75) | 1.12(0.75-1.68) | 1.00 | 0.82(0.54-1.26) | 0.71(0.34-1.46) | 0.80(0.53-1.20) | ||
| BMI (kg/m2) | ||||||||||
| <24 | 1.00 | 0.97(0.74-1.27) | 1.14(0.68-1.91) | 1.00(0.77-1.29) | 0.55 | 1.00 | 0.82(0.62-1.07) | 0.84(0.54-1.32) | 0.82(0.64-1.07) | 0.99 |
| ≥24 | 1.00 | 1.22(0.92-1.60) | 1.01(0.61-1.68) | 1.18(0.91-1.54) | 1.00 | 0.86(0.65-1.14) | 0.76(0.48-1.22) | 0.84(0.65-1.10) | ||
| Smoking | ||||||||||
| Yes | 1.00 | 1.16(0.91-1.49) | 1.23(0.77-1.97) | 1.17(0.92-1.49) | 0.23 | 1.00 | 0.82(0.64-1.06) | 0.78(0.51-1.19) | 0.82(0.64-1.04) | 0.77 |
| No | 1.00 | 1.01(0.74-1.37) | 0.85(0.48-1.53) | 0.98(0.73-1.32) | 1.00 | 0.87(0.64-1.19) | 0.86(0.51-1.45) | 0.87(0.65-1.17) | ||
| Drinking | ||||||||||
| Yes | 1.00 | 0.88(0.62-1.26) | 0.94(0.47-1.88) | 0.89(0.64-1.25) | 0.35 | 1.00 | 1.00(0.71-1.43) | 0.82(0.42-1.56) | 0.97(0.69-1.37) | 0.47 |
| No | 1.00 | 1.19(0.94-1.50) | 1.09(0.71-1.67) | 1.17(0.94-1.47) | 1.00 | 0.79(0.63-1.00) | 0.78(0.53-1.14) | 0.79(0.63-0.99)a | ||
ORs and 95% CIs were obtained from logistic regression analyses with adjustment for age, sex, BMI, smoking, drinking and family history of CHD except for the stratified factor.
a, OR is significant at the 0.05 level.
P, for interactions of CHD traditional risk factors with rs11722228 and rs4148152.