Table 2.
Mean expression fold changes of thermogenesis-related genes in adipose tissues of obese and normal-weight individuals
| Gene name | Gene description | Gene Bank | Mean expression fold change | P* | |||
|---|---|---|---|---|---|---|---|
| VAT-O | SAT-O | VAT-N | SAT-N | ||||
| ADRB1 | adrenergic receptor beta 1 | NM_000684 | 1.48 | 1.44 | 1.49 | 1.42 | NS |
| ADRB2 | adrenergic receptor beta 2 | NM_000024 | 0.97 | 1.70 | 2.10 | 3.81 | P < 0.0001 |
| ADRB3 | adrenergic receptor beta 3 | NM_000025 | 2.62 | 1.66 | 5.43 | 3.15 | P < 0.0001 |
| DIO1 | 5’-iodothyronine deiodinase type 1 | NM_000792 | 0.7 | 0.87 | 1.38 | 1.40 | NS |
| DIO2 | 5’-iodothyronine deiodinase type 2 | NM_001007023 | 0.55 | 1.62 | 2.13 | 2.60 | P < 0.0001 |
| THRA | thyroid hormone receptor α | NM_003250 | 1.79 | 1.70 | 6.03 | 4.18 | P < 0.0001 |
| THRB | thyroid hormone receptors β | NM_000461 | 0.57 | 0.58 | 1.92 | 1.13 | P < 0.0001 |
| UCP1 | uncoupling protein 1 | NM_021833 | 1.13 | 1.27 | 1.43 | 1.49 | NS |
| UCP2 | uncoupling protein 2 | NM_003355 | 1.79 | 1.30 | 5.10 | 3.64 | P < 0.0001 |
| UCP3 | uncoupling protein 3 | NM_003356 | 0.82 | 0.53 | 0.85 | 0.86 | NS |
*P values calculated with the Kruskal-Wallis analysis of variance.
N: normal-weight; O: obese; VAT: visceral adipose tissue; SAT subcutaneous adipose tissue; NS: not significant.