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Effect of intrperitoneal injection of bupropion on acetic acid-induced writhing test in mice. Bup (bupropion, 10, 20 and 40 mg/kg), indomethacin (10 mg/kg) and the vehicle were administered 30 min prior to acetic acid (1%) injection, the number of abdominal contractions was counted for each mouse for a period of 10 min starting 10 min after acetic acid injection. The values represent the mean of abdominal twitches ± SEM. *P<0.05; ***p<0.001 compared with control group.
