Fig. 2.

The antinociceptive activity of bupropion on paw licking during acute phase of formalin test. Different doses of buoropion (10, 20, 40 mg/kg) and vehicle were intraperitoneally administered 30 min prior to subplantar injection of formalin and time spent (seconds) for licking was measured during a 0-5 min immediately after formalin injection. Morphine (10 mg/kg, i.p.) was used as reference drug. Data are mean ± SEM. *P<0.05; ***P<0.001 compared with control group.