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The antinociceptive activity of bupropionin chronic phase of formalin test. Different doses of buoropion (10, 20, 40 mg/kg) and vehicle were intraperitoneally administered 30 min prior to subplantar injection of formalin and time spent for licking was measured during a 20-30 min period after formalin injection. Morphine (10 mg/kg, i.p.) was used as reference drug. Data are mean ± SEM. **P<0.01; ***P<0.001 compared with control group.
