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The antinociceptive activity of bupropion in hot plate test. Vehicle and bupropion (20, 40 mg/kg, i.p.) were administered 30 min prior to placement of the animal in hot plate and reaction time of mice was measured at 30 min intervals until 2 h and percent of maximal possible antinociceptive effect (MPE%) was calculated for each time and compared. Morphine (10 mg/kg, i.p.) was used as reference drug. Data are mean ± SEM. **P<0.01; ***P<0.001 compared with control group.
