Fig. 4.

Effect of loperamide (20 nM-12.8 μM) and 6-(4- hydroxy-3-methoxyphenyl)-hexanonic acid (20-630 μM) on tension development to 5-HT (2 μM) in isolated ileum of rat. Ordinate scale: ileum contractile response expressed as percent of initial control response. Abscissa scale: log10 concentration of drugs. The points are mean and the vertical bars show the SEM (n=6). There is no statistical significant differences in vehicle treated (DMSO) time-matched control over the course of study (ANOVA).