. 2014 Dec 23;9(3):1201–1206. doi: 10.3892/ol.2014.2823

Table I.

Prognostic factors of disease-specific survival in 151 hepatocellular carcinoma patients.

		Univariate			Multivariate

Variables	n	Hazard ratio	95% CI	P-value	Hazard ratio	95% CI	P-value
Age (≥65 years)	84	1.92	1.07–3.57	0.030^a	1.60	0.87–3.05	0.133
Gender (male)	126	1.27	0.60–3.13	0.553
Background liver (cirrhosis)	54	1.58	0.88–2.81	0.123
Pugh-Child’s classification (B)	11	0.93	0.28–2.32	0.889
α-FP (>20 ng/ml)	70	1.90	1.07–3.42	0.029^a	1.32	0.69–2.50	0.395
PIVKA II (>40 mAU/ml)	93	2.10	1.14–4.07	0.016^a	1.20	0.60–2.53	0.610
Tumor multiplicity (multiple)	34	2.09	1.11–3.76	0.023^a	1.31	0.67–2.48	0.418
Tumor size (≥3.0 cm)	104	2.20	1.13–4.71	0.020^a	1.37	0.61–3.36	0.453
Tumor differentiation (well)	35	0.55	0.25–1.10	0.095
Growth type (invasive growth)	24	1.44	0.69–2.76	0.318
Serosal infiltration	37	2.51	1.32–4.61	0.006^a	1.47	0.70–3.02	0.304
Formation of capsule	104	1.05	0.57–2.02	0.884
Infiltration to capsule	83	1.20	0.67–2.18	0.537
Septum formation	98	0.87	0.49–1.60	0.651
Vascular invasion	37	3.40	1.87–6.07	<0.001^a	2.42	1.17–4.97	0.017^a
Margin status (positive)	28	2.64	1.42–4.73	0.003^a	2.84	1.48–5.36	0.002^a
Increased expression of MAGE-D2 mRNA	66	1.96	1.10–3.54	0.022^a	2.65	1.43–4.98	0.002^a

Statistically significant (P<0.05).

Univariate and multivariate analyses were performed using the log-rank test and the Cox proportional hazards model, respectively. CI, confidence interval; α-FP, α-fetoprotein; PIVKA, protein induced by vitamin K antagonists; MAGE-D2, melanoma-associated antigen-D2.