Table I.
Dox-induced cross-resistance to Dox and sunitinib in HMEC-1 endothelial cells.
| HMEC-1 | HMECd1 | HMECd2 | |||
|---|---|---|---|---|---|
|
|
|
|
|||
| Agents | IC50, μM | IC50, μM | RI | IC50, μM | RI |
| Sunitinib | 4.271±0.501 | 8.585±0.642 | 2.01a | 19.252±0.855 | 4.51a |
| Doxorubicin | 0.056±0.006 | 0.812±0.050 | 14.50a | 1.209±0.085 | 21.60a |
The cells were treated as described in the main text and tested with MTS assay. The RI was determined as the IC50 of Dox-treated HMECd1 or HMECd2 cells divided by the IC50 of Dox-treated HMEC-1 cells.
a
P<0.05, vs. HMEC-1 cells.
Dox, doxorubicin; RI, resistance index; IC50, half maximal inhibitory concentration.