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Effect of different Ad-p53 administration methods on MMP2 protein expression levels in tumor tissues. (A) Representative immunohistochemical images in the control, p53 and p53 + US groups. Arrow, positive immunohistochemical staining for MMP2. (B) Integral optical density results calculated using the pathological image analysis system. n=5; **P<0.01, vs. the control group. Ad-p53, adenovirus-p53; MMP2, matrix metalloprotein 2; US, ultrasonic irradiation.
