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. 2015 Feb 3;4:186. doi: 10.3389/fcimb.2014.00186

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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The C. burnetii Dot/Icm T4SS cannot secrete O. tsutsugamushi Anks. THP-1 macrophage-like cells were infected with C. burnetii transformants expressing CyaA-tagged O. tsutsugamushi Anks, CvpA (+), or CyaA alone (−). Bars represent the fold change in intracellular cAMP concentration for host cells infected with wild type C. burnetii transformants expressing CyaA-fusions relative to control cells infected with transformants expressing CyaA alone. Results are representative of two independent experiments.