Table 1.
Fifty-five genes differentially expressed between FVPTCs and FAs and comparison with TN sample expression
| Gene name | Gene symbol | FVPTC vs. FA | FVPTC vs. TN | FA vs. TN | |||
|---|---|---|---|---|---|---|---|
| FC1 | P 2 | FC1 | P | FC1 | P | ||
| gamma-aminobutyric acid (GABA) B receptor, 2 | GABBR2 | 7.09 | 1.06E-07 | 8.51 | 2.99E-08 | 1.20 | 4.10E-01 |
| neuronal cell adhesion molecule | NRCAM | 4.09 | 1.64E-07 | 4.06 | 1.76E-07 | -1.01 | 9.64E-01 |
| extracellular matrix protein 1 | ECM1 | 18.36 | 5.77E-07 | 15.49 | 1.28E-06 | -1.19 | 6.44E-01 |
| heparan sulfate 6-O-sulfotransferase 2 | HS6ST2 | 5.07 | 8.60E-07 | 3.77 | 1.11E-05 | -1.35 | 1.71E-01 |
| retinoid X receptor, gamma | RXRG | 13.16 | 8.69E-07 | 15.64 | 3.64E-07 | 1.19 | 6.08E-01 |
| insulin-like growth factor 2 mRNA binding protein 2 | IGF2BP2 | 5.88 | 1.10E-06 | 4.90 | 4.45E-06 | -1.20 | 4.40E-01 |
| cellular retinoic acid binding protein 2 | CRABP2 | 4.48 | 1.18E-06 | 4.20 | 2.07E-06 | -1.07 | 7.50E-01 |
| high mobility group AT-hook 2 | HMGA2 | 5.15 | 1.33E-06 | 3.17 | 8.64E-05 | -1.62 | 3.91E-02 |
| interaction protein for cytohesin exchange factors 1 | IPCEF1 | -6.48 | 1.39E-06 | -3.55 | 1.32E-04 | 1.82 | 2.70E-02 |
| G protein-coupled receptor 155 | GPR155 | -2.83 | 2.09E-06 | -1.31 | 8.64E-02 | 2.16 | 4.76E-05 |
| Purkinje cell protein 4 | PCP4 | -2.47 | 2.17E-06 | -1.50 | 5.96E-03 | 1.65 | 9.10E-04 |
| dipeptidyl-peptidase 10 (non-functional) | DPP10 | 3.85 | 2.22E-06 | 1.99 | 2.34E-03 | -1.93 | 2.49E-03 |
| low density lipoprotein receptor-related protein 4 | LRP4 | 8.23 | 3.70E-06 | 13.56 | 2.22E-07 | 1.65 | 1.16E-01 |
| chondroitin sulfate N-acetylgalactosaminyltransferase 1 | CSGALNACT1 | -3.34 | 4.06E-06 | -1.13 | 5.01E-01 | 2.95 | 9.50E-06 |
| fibronectin type III domain containing 4 | FNDC4 | 3.65 | 5.75E-06 | 2.48 | 2.85E-04 | -1.47 | 6.15E-02 |
| leucine-rich repeat kinase 2 | LRRK2 | 20.97 | 6.06E-06 | 31.24 | 1.27E-06 | 1.49 | 3.92E-01 |
| odz, odd Oz/ten-m homolog 1 (Drosophila) | ODZ1 | 13.95 | 6.87E-06 | 13.63 | 7.66E-06 | -1.02 | 9.54E-01 |
| lipase, member H | LIPH | 18.83 | 7.39E-06 | 20.52 | 5.19E-06 | 1.09 | 8.49E-01 |
| glutamate receptor interacting protein 1 | GRIP1 | -2.52 | 7.61E-06 | -1.24 | 1.66E-01 | 2.04 | 9.33E-05 |
| slit homolog 1 (Drosophila) | SLIT1 | 6.12 | 8.81E-06 | 9.01 | 7.51E-07 | 1.47 | 1.83E-01 |
| protocadherin 7 | PCDH7 | 3.46 | 8.83E-06 | 2.96 | 4.20E-05 | -1.17 | 4.26E-01 |
| proteolipid protein 1 | PLP1 | 10.00 | 8.88E-06 | 4.92 | 4.63E-04 | -2.03 | 6.14E-02 |
| SOGA family member 3 | SOGA3 | 2.54 | 9.38E-06 | 2.44 | 1.59E-05 | -1.04 | 7.81E-01 |
| patched domain containing 4 | PTCHD4 | 9.30 | 1.03E-05 | 3.03 | 7.04E-03 | -3.07 | 4.90E-03 |
| UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosamine | GALNT7 | 3.57 | 1.04E-05 | 8.03 | 1.35E-08 | 2.25 | 7.59E-04 |
| glutaminyl-peptide cyclotransferase | QPCT | 6.05 | 1.18E-05 | 5.68 | 1.79E-05 | -1.06 | 8.27E-01 |
| transcription factor CP2-like 1 | TFCP2L1 | -4.40 | 1.42E-05 | -1.80 | 2.95E-02 | 2.45 | 1.51E-03 |
| cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) | CWH43 | -4.73 | 1.47E-05 | -2.32 | 4.77E-03 | 2.04 | 1.10E-02 |
| pleiomorphic adenoma gene 1 | PLAG1 | 5.46 | 1.47E-05 | 3.88 | 1.75E-04 | -1.41 | 2.26E-01 |
| UDP-galactose-4-epimerase | GALE | 2.74 | 1.52E-05 | 2.39 | 8.06E-05 | -1.15 | 4.04E-01 |
| neurotrophic tyrosine kinase, receptor, type 3 | NTRK3 | 3.64 | 1.75E-05 | 2.68 | 3.21E-04 | -1.36 | 1.61E-01 |
| v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | KIT | -4.84 | 1.93E-05 | -1.47 | 1.72E-01 | 3.30 | 2.53E-04 |
| acid phosphatase, prostate | ACPP | 2.41 | 2.59E-0 | 2.48 | 1.72E-05 | 1.03 | 8.34E-01 |
| diacylglycerol kinase, iota | DGKI | -3.53 | 3.16E-05 | -1.88 | 1.19E-02 | 1.87 | 9.87E-03 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | VDR | 2.62 | 3.26E-05 | 2.63 | 3.09E-05 | 1.00 | 9.79E-01 |
| family with sequence similarity 70, member A | FAM70A | 2.74 | 3.30E-05 | 1.05 | 7.91E-01 | -2.61 | 3.66E-05 |
| uncharacterized LOC100129434 | LOC100129434 | -2.60 | 3.63E-05 | -1.37 | 8.73E-02 | 1.90 | 1.22E-03 |
| spermatogenesis associated 18 | SPATA18 | 2.70 | 4.41E-05 | 1.95 | 1.93E-03 | -1.38 | 8.18E-02 |
| retrotransposon gag domain containing 4 | RGAG4 | 3.13 | 4.80E-05 | 4.19 | 3.16E-06 | 1.34 | 1.66E-01 |
| zinc finger protein 521 | ZNF521 | 2.72 | 5.44E-05 | 4.00 | 1.03E-06 | 1.47 | 4.63E-02 |
| pleckstrin and Sec7 domain containing 3 | PSD3 | 3.50 | 5.69E-05 | 8.64 | 5.67E-08 | 2.47 | 9.62E-04 |
| synapse differentiation inducing 1 | SYNDIG1 | -2.67 | 5.72E-05 | -1.47 | 5.38E-02 | 1.82 | 3.60E-03 |
| LIM domain only 3 (rhombotin-like 2) | LMO3 | 2.66 | 5.86E-05 | 5.59 | 4.25E-08 | 2.10 | 6.13E-04 |
| adhesion molecule with Ig-like domain 2 | AMIGO2 | 2.87 | 5.90E-05 | 2.51 | 2.35E-04 | -1.14 | 5.02E-01 |
| RNA binding protein with multiple splicing 2 | RBPMS2 | -2.73 | 6.11E-05 | 1.01 | 9.51E-01 | 2.76 | 3.45E-05 |
| integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | ITGA2 | 2.72 | 6.37E-05 | 5.15 | 1.30E-07 | 1.89 | 2.75E-03 |
| sodium channel, voltage-gated, type IV, alpha subunit | SCN4A | 2.29 | 6.51E-05 | 2.70 | 8.15E-06 | 1.18 | 2.95E-01 |
| neuro-oncological ventral antigen 1 | NOVA1 | 3.86 | 7.79E-05 | 2.49 | 2.83E-03 | -1.55 | 9.88E-02 |
| SMAD family member 9 | SMAD9 | -3.03 | 7.91E-05 | -1.18 | 4.60E-01 | 2.57 | 2.66E-04 |
| Sciellin | SCEL | 5.85 | 8.10E-05 | 6.23 | 5.50E-05 | 1.07 | 8.48E-01 |
| SLC26A8 | SLC26A8 | 2.71 | 8.28E-05 | 1.45 | 7.47E-02 | -1.87 | 3.65E-03 |
| serine-rich and transmembrane domain containing 1 | SERTM1 | -5.94 | 8.38E-05 | -1.58 | 2.05E-01 | 3.76 | 9.96E-04 |
| calpain 3 (p93) | CAPN3 | 2.23 | 8.41E-05 | 2.93 | 2.60E-06 | 1.32 | 8.34E-02 |
| immunoglobulin superfamily, member 1 | IGSF1 | 8.63 | 8.51E-05 | 9.28 | 5.97E-05 | 1.07 | 8.60E-01 |
| primary ciliary dyskinesia protein 1 | PCDP1 | -2.17 | 8.74E-05 | -1.23 | 1.91E-01 | 1.77 | 1.15E-03 |
1FC, fold change;2p-value with FDR < 0.05 and fold change cutoff > 2;-, downregulated in FVPTCs vs. FAs, downregulated in FVPTCs vs. TN, and downregulated in FAs vs. TN.