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Protein cleavage by γ-secretase results in downstream signaling purported to be of relevance for Alzheimer’s disease and development of the central nervous system. APP = amyloid precursor protein; ApoE = apolipoprotein E; NGF = nerve growth factor; NICD = Notch intracellular domain; PS1 = Presenilin-1; p75ICD = p75 intracellular domain; VLDLR = very-low-density lipoprotein receptor; ApoER2 = apolipoprotein E receptor 2; CTF = C-terminal fragment.
