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. 2015 Feb 2;208(3):259–271. doi: 10.1083/jcb.201410071

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© 2015 Trimble and Grinstein

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Figure 3. — Attraction and repulsion of mobile proteins. Mobile membrane proteins or lipids can be immobilized within microdomains by stereospecific, hydrophobic, or electrostatic interactions. A protein bearing a PH domain is shown to be recruited to a patch rich in its ligand lipid, e.g., PtdIns(4,5)P₂. The negative charge of PtdIns(4,5)P₂ (designated as PIP₂ in the figures for brevity; approximately −4 at physiological pH) is also shown as deflecting proteins with a negatively charged cytosolic domain.