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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Hepatology. 2015 Jan 5;61(2):460–470. doi: 10.1002/hep.27344

Fig 1. The haplotype at rs1990760 and rs3747517 coding for histidine at position 843 and threonine at position 946 in MDA-5 is associated with spontaneous clearance of HCV infection.

Fig 1

A: The frequency distribution in the combined cohorts 1 and 2 of the four possible MDA-5 haplotypes defined by the two SNPs rs3747517 and rs1990760 is depicted. At rs3747517 the minor allele in the European population (T) codes for histidine at position 843 and the major allele (C) for arginine. At rs1990760 the minor allele (C) codes for alanine at position 946 and the major allele (T) for threonine. The haplotype coding for H843/T946 is suppressed in the group with chronic hepatitis C and associated with clearance of HCV infection. B: The frequency of haplotypes encoding H843/T946 was calculated in the group with chronic hepatitis versus the group with spontaneous resolved hepatitis and compared to the distribution of the combined frequency of the three other possible alleles. C: The frequency of individuals that are carriers, with either heterozygous or homozygous genotypes, of the H843/T946 haplotype versus individuals that do not carry this haplotype was compared in the groups with chronic hepatitis and spontaneous resolved hepatitis respectively. Odds ratios (OR) and 95% confidence intervals are depicted. p-values were calculated using the x2 test.