Table 2.
Allele frequency analysis of non-synonymous, coding SNPs in RIG-I, MDA-5, MAVS and Lgp2 as well as rs12979860 in the IL-28B promoter in individuals with chronic hepatitis C and spontaneously resolved hepatitis C in cohort 1
| SNP ID and alleles | Allele frequency (%) | p-value | OR (95% CI) |
|||
|---|---|---|---|---|---|---|
| Control | CH | SRH | ||||
| RIG-I: R7C (rs10813831) G/A | G A |
73.4 26.6 |
71.6 28.4 |
68.4 31.6 |
0.465 | 0.86 (0.57 – 1.29) |
| D580E (rs17217280) A/T | A T |
84.2 15.8 |
88.8 11.2 |
88.3 11.7 |
0.881 | 1.05 (0.59 – 1.89) |
| S183I (rs11795404) G/T | G T |
100 0 |
100 0 |
100 0 |
– | – |
| T260P (rs35527044) A/C | A C |
100 0 |
100 0 |
100 0 |
– | – |
| I406T (rs951618) T/C | T C |
100 0 |
100 0 |
100 0 |
– | – |
| F789L (rs35253851) C/A | C A |
100 0 |
100 0 |
100 0 |
– | – |
| MDA-5: T946A (rs1990760) T/C | T C |
60.0 40.0 |
62.1 37.9 |
55.3 44.7 |
0.171 | 1.32 (0.52 – 1.10) |
| R843H (rs3747517) C/T |
C T |
72.4 27.6 |
72.1 27.9 |
60.8 39.2 |
0.013 |
1.67 (1.12 – 2.48) |
| H460R (rs10930046) T/C | T C |
98.8 1.2 |
99.2 0.8 |
99.4 0.6 |
0.876 | 1.19 (1.12 – 11.61) |
| I923V (rs35667974) A/G | A G |
97.8 2.2 |
98.8 1.2 |
96.6 3.4 |
0.123 | 2.78 (0.73 – 10.52) |
| Mavs: Q198K (rs7262903) C/A | C A |
85.1 14.9 |
85.5 14.5 |
80.5 19.5 |
0.154 | 0.70 (0.43 – 1.14) |
| S409F (rs7269320) C/T | C T |
84.9 15.1 |
86.1 13.9 |
81.2 18.8 |
0.149 | 1.44 (0.88 – 2.36) |
| Lgp2: Q425R (rs2074158) A/G | A G |
83.3 16.7 |
86.6 13.4 |
88.2 11.8 |
0.673 | 0.87 (0.49 – 1.54) |
| R523Q (rs2074160) G/A | G A |
97.8 2.2 |
97.5 2.5 |
98.1 1.9 |
0.683 | 1.31 (0.36 – 4.83) |
| IL-28B: noncoding (rs12979860) |
T C |
n.d. |
41.8 58.2 |
22.4 77.6 |
2.5 × 10−5 |
2.4 (1.62 – 3.83) |
p-value by x2 test for allele distribution comparing CH versus SRH; CH, chronic hepatitis. SRH, spontaneously resolved hepatitis. OR, odds ratio comparing CH versus SRH. CI, confidence interval. n.d., not determined.