Table 1. PAML analysis of FTO.

Model	Parameter Estimates	In L	LRT
			Models	2Δl	d.f.	p-value
M0	ω0 = 0.1616	−1462.43	M0 vs. free-ratio	63.74	66	0.58
free-ratio	variable	−1430.56
M3	p0 = 0.40765, p1 = 0.39476, p2 = 0.19759, ω0 = 0.00264. ω1 = 0.12330, ω2 = 0.90116	−1365.70	M0 vs. M3	193.47	4	< 0.001
M1a	p0 = 0.79894, p1 = 0.20106, ω0 = 0.05695, ω1 = 1.00000	−1378.39	M1a vs. M2a	0.61	2	0.74
M2a	p0 = 0.79860, p1 = 0.16914, p2 = 0.03227, ω0 = 0.06053, ω1 = 1.00000, ω2 = 1.90635	−1378.09
M7	p = 0.21277, q = 0.75616	−1367.96	M7 vs. M8	3.71	2	0.22
M8	p0 = 0.94790, p = 0.26173, q = 1.37577 (p1 = 0.05210), w = 1.63117	−1366.10

All values computed under default settings. InL: log likelihood, LRT = likelihood ratio test to detect positive selection, d.f. = degrees of freedom.