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. 2015 Feb 3;10(2):e0117601. doi: 10.1371/journal.pone.0117601

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© 2015 Bajic et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — Hot Plate test was done in the afternoon on day 7 of treatment to evaluate development of antinociceptive tolerance. Chronic morphine administration (10 mg/kg sc twice-daily for 6.5 days; n = 6) was associated with development of antinociceptive tolerance in comparison to saline control group (n = 6). Chronic mecamylamine (Mec) administration (2 mg/kg sc twice-daily for 6.5 days; n = 4) did not change morphine antinociceptive effect. In addition, when given chronically with morphine, mecamylamine did not change development of antinociceptive tolerance (n = 5). Results are presented as a percentage of maximum possible effect (%MPE ± SD) according to the method of Harris and Pierson [38] to construct dose-response curves for morphine’s antinociceptive effect. Two-way ANOVA shows a significant effect of morphine (F(1,17) = 377.69, p<0.0001 at 10 mg/kg testing dose), while there is no significant effect of mecamylamine nor interaction effect. **, p<0.01.