Table 1.

Dutch Lipid Clinic Network criteria for diagnosis of heterozygous FH in adults

Criterion1	Points
Family history
First-degree relative with known premature (<55 years, men; <60 years, women) CHD or First-degree relative with known LDL cholesterol >95th percentile by age and sex for country	1
First-degree relative with tendon xanthoma and/or corneal arcus or Child(ren) <18 years with LDL cholesterol >95th percentile by age and sex for country	2
Clinical history
Subject has premature (<55 years, men; <60 years, women) CHD	2
Subject has premature (<55 years, men; <60 years, women) cerebral or peripheral vascular disease	1
Physical examination
Tendon xanthoma	6
Corneal arcus in a person <45 years	4
Biochemical results (LDL-cholesterol)
>8.5 mmol/L (>325 mg/dL)	8
6.5–8.4 mmol/L (251–325 mg/dL)	5
5.0–6.4 mmol/L (191–250 mg/dL)	3
4.0–4.9 mmol/L (155–190 mg/dL)	1
Molecular genetic testing (DNA analysis)
Causative mutation shown in the LDLR, APOB, or PCSK9 genes	8

Notes: >8 points: definite FH; 6–8 points: probable FH; 3–5 points: possible FH. The APOB and PCSK9 genes were added to the genetic testing.

Abbreviations: FH, familial hypercholesterolemia; CHD, coronary heart disease; LDL, low-density lipoprotein; DNA, deoxyribonucleic acid; LDLR, LDL receptor; APOB, apolipoprotein B; PCSK9, proprotein convertase subtilisin/kexin type 9.