Table 3.
Summary of histological investigations of 42 patients: 1 local relapse in 1 patient and 29 lymph node metastases in 3 other patients were false-negative. All other lesions (n = 416) were true-positive or true-negative
| All Lesions: | False-Negative | False-Positive | True-Negative | True-Positive |
|---|---|---|---|---|
| Prostate Cancer | 0 | 0 | 2 | 15 |
| Soft Tissue Met. | 0 | 0 | 4 | 11 |
| Lymph Node Met. | 29 | 0 | 310 | 65 |
| Local Relapse | 1 | 0 | 2 | 7 |
| Lesion-based NPV and PPV | 30/348 (8.6 %) | 0/98 (0 %) | 318/348 (91.4 % NPV) | 98/98 (100 % PPV) |
| Lesion-based Specificity and Sensitivity | 30/128 (23.4 %) | 0/318 (0 %) | 318/318 (100 % Specificity) | 98/128 (76.6 % Sensitivity) |
| Patients: | False-Negative | False-Positive | True-Negative | True-Positive |
| 1 | 0 | 0 | 0 | 1 (PCa) |
| 2 | 0 | 0 | 1 (LN) | 1 (LN) |
| 3 | 0 | 0 | 2 (LN) | 1 (LN) |
| 4 | 0 | 0 | 9 (LN) | 3 (ST) |
| 5 | 0 | 0 | 15 (LN) | 1+28 (ST/LN) |
| 6 | 0 | 0 | 11 (LN) | 1 (ST) |
| 7 | 0 | 0 | 1+31 (ST/LN) | 1+1 (ST/LN) |
| 8 | 0 | 0 | 1 (ST) | 2 (ST) |
| 9 | 0 | 0 | 1 (LR) | 0 |
| 10 | 0 | 0 | 11 (LN) | 1 (PCa) |
| 11 | 0 | 0 | 42 (LN) | 1 (PCa) |
| 12 | 0 | 0 | 12 (LN) | 1 (PCa) |
| 13 | 0 | 0 | 1 (PCa) | 0 |
| 14 | 0 | 0 | 17 (LN) | 1 (PCa) |
| 15 | 0 | 0 | 14 (LN) | 1 (PCa) |
| 16 | 0 | 0 | 13 (LN) | 1 (PCa) |
| 17 | 0 | 0 | 0 | 1 (PCa) |
| 18 | 0 | 0 | 37 (LN) | 1 (LR) |
| 19 | 0 | 0 | 0 | 1 (LR) |
| 20 | 0 | 0 | 3 (LN) | 1 (LR) |
| 21 | 0 | 0 | 0 | 7 (LN) |
| 22 | 0 | 0 | 0 | 1 (ST) |
| 23 | 0 | 0 | 0 | 1 (PCa) |
| 24 | 0 | 0 | 0 | 1 (PCa) |
| 25 | 0 | 0 | 7 (LN) | 1+2+2 (PCa/ST/LN) |
| 26 | 1 (LN) | 0 | 0 | 1 (PCa) |
| 27 | 0 | 0 | 0 | 1 (PCa) |
| 28 | 0 | 0 | 0 | 1 (LR) |
| 29 | 0 | 0 | 24 (LN) | 5+1 (LN/LR) |
| 30 | 0 | 0 | 1 (LR) | 0 |
| 31 | 1 (LR) | 0 | 0 | 0 |
| 32 | 0 | 0 | 0 | 1 (LN) |
| 33 | 0 | 0 | 0 | 1 (PCa) |
| 34 | 26 (LN) | 0 | 1+32 (ST/LN) | 7 (LN) |
| 35 | 0 | 0 | 1+16 (ST/LN) | 1 (LN) |
| 36 | 0 | 0 | 8 (LN) | 1+1 (LR/LN) |
| 37 | 2 (LN) | 0 | 0 | 4 (LN) |
| 38 | 0 | 0 | 1 (PCa) | 0 |
| 39 | 0 | 0 | 0 | 1 (PCa) |
| 40 | 0 | 0 | 0 | 1 (PCa) |
| 41 | 0 | 0 | 2 (LN) | 5 (LN) |
| 42 | 0 | 0 | 3 (LN) | 1 (LR) |
| Patient-based Analysisa | 5/42 (11.9 %) | not existing | not existing | 37/42 (88.1 % Sensitivity)a |
The false-negative LN metastases of patients 35 and 37 were located in the same region as the PET-positive LNs
PCa prostate cancer within the prostate gland, LN lymph node (metastasis), ST soft tissue (metastasis), LR local relapse of PCa
aAs described in the “Materials and methods” section, a patient-based analysis of specificity, NPV and PPV is not possible